Background

Though it is obvious that bones have several important functions in the human body, there was much research done before and during the process of working on this project on specific mouse bone geometry and biomechanics relating to bones. Below are a few of the sources that we referred to while working on the project.

Articles:

1. Lekszycki T. Functional adaptation of bone as an optimal control problem. Journal of Theoretical and Applied Mechanics. 2005;43(3):555-74.

This article offers a great review on how bones adapt to their surroundings, a process called remodeling. It includes a biological perspective, explaining the different cells that comprise bones, as well as a  mechanical perspective which includes descriptions about Wolff's Law and the impact of load on bones. Several mathematical formulas are also explained and used in the article in order to predict the optimal response of bones to varying stimuli. To access the article, click here. 

2. Di Masso R, Zerpa CM, Silva PS, Font MT. Femoral morphometry and femur length in mice selected for different body conformations. A potential animal model suitable for QTLs mapping. Arch Tierz. 2007;50(3):309-19.

The article above was used mainly for its research. The article presents several tables listing the mean femur lengths of mice of different genders and body confirmations. Using this research, the group was able to extrapolate an appropriate length to make our CREO model. Our initial CREO model was a simple cylinder and can be viewed here. To read the article, please click here. 

Physics, Relevant Mathematical Relationships, and Bone Geometry:

The diagrams above illustrate the mathematical relationships that are used to calculate values such as force displacement, maximum flexural strength, and the moment of inertia for a bone of elliptical geometry. Depending on how we change our bone geometry, the equations listed above will slightly change.